--- tags: - sentence-transformers - sentence-similarity - feature-extraction - generated_from_trainer - dataset_size:18280 - loss:MultipleNegativesRankingLoss base_model: intfloat/multilingual-e5-large-instruct widget: - source_sentence: 'query: Uncovering a novel recurring genetic anomaly in human #PluripotentStemCells through sequencing over 500 distinct #iPSCell lines: mutations encoding BCOR truncated variants identified in 26% of blood‐derived iPSCs. Key finding by @user ⤵️' sentences: - 'passage: title: Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells abstract: Abstract We explored human induced pluripotent stem cells (hiPSCs) derived from different tissues to gain insights into genomic integrity at single-nucleotide resolution. We used genome sequencing data from two large hiPSC repositories involving 696 hiPSCs and daughter subclones. We find ultraviolet light (UV)-related damage in ~72% of skin fibroblast-derived hiPSCs (F-hiPSCs), occasionally resulting in substantial mutagenesis (up to 15 mutations per megabase). We demonstrate remarkable genomic heterogeneity between independent F-hiPSC clones derived during the same round of reprogramming due to oligoclonal fibroblast populations. In contrast, blood-derived hiPSCs (B-hiPSCs) had fewer mutations and no UV damage but a high prevalence of acquired BCOR mutations (26.9% of lines).' - 'passage: title: Long COVID is associated with extensive in-vivo neuroinflammation on [ 18 F]DPA-714 PET abstract: Summary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology of long COVID is unknown. Here we present in-vivo evidence of widespread neuroinflammation in long COVID, using a quantitative assessment, [ 18 F]DPA-714 PET, in two long COVID patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both patients with long COVID had widespread increases in [ 18 F]DPA-714 binding throughout the brain. Quantitative measures of binding (BP ND values) were increased on average by 121% and 76%, respectively. This implicates profound neuroinflammation in the pathophysiology of long COVID.' - 'passage: ive individuals with MPNs and reconstructed lineage histories of individual HSCs using somatic mutation patterns. title: Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms We found that JAK2-V617F mutations occurred in a single HSC several decades before MPN diagnosis-at age 9 ± 2 years in a 34-year-old individual and at age 19 ± 3 years in a 63-year-old individual-and found that mutant HSCs have a selective advantage in both individuals. These results highlight the potential of harnessing somatic mutations to reconstruct cancer lineages.' - source_sentence: 'query: This study verifies what many MDs have been pondering: that "Long Covid" defined as a blurred array of symptoms is widely prevalent and typically is unrelated to a Covid infection.' sentences: - 'passage: factor for PCC was symptom severity at baseline (RR, 1.41; 95% CI, 1.27-1.56). title: Prevalence and Characteristics Associated With Post–COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults Low physical activity (RR, 0.96; 95% CI, 0.92-1.00) and loneliness (RR, 1.01; 95% CI, 1.00-1.02) were also associated, while biological markers were not. Symptom severity correlated with personality traits.The persistent symptoms and disability that characterize PCC are associated with factors other than SARS-CoV-2 infection, including psychosocial factors. This finding raises questions about the utility of the World Health Organization case definition and has implications for the planning of health care services as well as for further research on PCC.' - 'passage: title: Potential impact of seasonal forcing on a SARS-CoV-2 pandemic abstract: A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 80,000 confirmed infections and 2,700 fatalities (as of Feb 27, 2020). Imported cases and transmission clusters of various sizes have been reported globally suggesting a pandemic is likely. Here, we explore how seasonal variation in transmissibility could modulate a SARS-CoV-2 pandemic. Data from routine diagnostics show a strong and consistent seasonal variation of the four endemic coronaviruses (229E, HKU1, NL63, OC43) and we parameterize our model for SARS-CoV-2 using these data. The model allows for many subpopulations of different size with variable parameters. Simulations of different scenarios show that plausible parameters result in a small peak in early 2020 in temperate regions of the Northern Hemisphere and a larger peak in winter 2020/2021. Variation in transmission and migration rates can result in substantial variation in prevalence between regions.' - 'passage: =72). The most common Long COVID symptom was fatigue (64.8%) followed by cough (32.4%). title: Prevalence, characteristics, and predictors of Long COVID among diagnosed cases of COVID-19 Statistically significant predictors of Long COVID were - Pre-existing medical conditions (Adjusted Odds ratio (aOR)=2.00, 95% CI: 1.16,3.44), having a more significant number of symptoms during acute phase of COVID-19 disease (aOR=11.24, 95% CI: 4.00,31.51), two doses of COVID-19 vaccination (aOR=2.32, 95% CI: 1.17,4.58), the severity of illness (aOR=5.71, 95% CI: 3.00,10.89) and being admitted to hospital (Odds ratio (OR)=3.89, 95% CI: 2.49,6.08). Conclusion A considerable proportion of COVID-19 cases reported Long COVID symptoms. More research is needed in Long COVID to objectively assess the symptoms and find the biological and radiological markers.' - source_sentence: 'query: COVID-19 Vaccine Shots for Young Adults: A Cost-Benefit Evaluation and Five Moral Arguments opposing Mandates in Universities @SSRN' sentences: - 'passage: title: COVID-19 vaccine boosters for young adults: a risk benefit assessment and ethical analysis of mandate policies at universities abstract: In 2022, students at North American universities with third-dose COVID-19 vaccine mandates risk disenrolment if unvaccinated. To assess the appropriateness of booster mandates in this age group, we combine empirical risk-benefit assessment and ethical analysis. To prevent one COVID-19 hospitalisation over a 6-month period, we estimate that 31 207–42 836 young adults aged 18–29 years must receive a third mRNA vaccine. Booster mandates in young adults are expected to cause a net harm: per COVID-19 hospitalisation prevented, we anticipate at least 18.5 serious adverse events from mRNA vaccines, including 1.5–4.6 booster-associated myopericarditis cases in males (typically requiring hospitalisation). We also anticipate 1430–4626 cases of grade ≥3 reactogenicity interfering with daily activities (although typically not requiring hospitalisation).' - 'passage: and 9396±2254 ppm with FFP2 respirators. title: Inhaled CO 2 concentration while wearing face masks: a pilot study using capnography The proportion of the sample showing a CO 2 concentration higher than the 5000 ppm acceptable exposure threshold recommended for workers was 40.2% while wearing surgical masks, 99.0% while wearing FFP2 respirators. The mean blood oxygen saturation remained >96%, and the mean end-tidal CO 2 Multi‐disciplinary collaborative consensus guidance statement on the assessment and treatment of autonomic dysfunction in patients with post‐acute sequelae of SARS‐CoV ‐2 infection ( PASC ) abstract: Although many people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recover completely, others are left with long-lasting symptoms that persist for at least 4 weeks, a condition referred to by the National Institutes of Health (NIH) as post-acute sequelae of SARS-CoV-2 infection (PASC).1 The Centers for Disease Control and Prevention (CDC) defines post-COVID (coronavirus disease) conditions as the wide range of health consequences that are present for four or more weeks after infection with SARS-CoV-2,2 whereas the World Health Organization (WHO) refers to post-COVID condition as symptoms that persist beyond 12 weeks after an initial infection, last for at least 2 months,' - 'passage: title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management abstract: Despite myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) affecting millions of people worldwide, many clinicians lack the knowledge to appropriately diagnose or manage ME/CFS. Unfortunately, clinical guidance has been scarce, obsolete, or potentially harmful. Consequently, up to 91% of patients in the United States remain undiagnosed, and those diagnosed often receive inappropriate treatment. These problems are of increasing importance because after acute COVID-19, a significant percentage of people remain ill for many months with an illness similar to ME/CFS. In 2015, the US National Academy of Medicine published new evidence-based clinical diagnostic criteria that have been adopted by the US Centers for Disease Control and Prevention. Furthermore, the United States and other governments as well as major health care organizations have recently withdrawn graded exercise and cognitive-behavioral therapy as the treatment of choice for patients with ME/CFS.' pipeline_tag: sentence-similarity library_name: sentence-transformers metrics: - cosine_accuracy@1 - cosine_accuracy@3 - cosine_accuracy@5 - cosine_accuracy@10 - cosine_precision@1 - cosine_precision@3 - cosine_precision@5 - cosine_precision@10 - cosine_recall@1 - cosine_recall@3 - cosine_recall@5 - cosine_recall@10 - cosine_ndcg@10 - cosine_mrr@10 - cosine_map@100 model-index: - name: SentenceTransformer based on intfloat/multilingual-e5-large-instruct results: - task: type: information-retrieval name: Information Retrieval dataset: name: CT26 dev split type: CT26-dev-split metrics: - type: cosine_accuracy@1 value: 0.6656282450674974 name: Cosine Accuracy@1 - type: cosine_accuracy@3 value: 0.8348909657320872 name: Cosine Accuracy@3 - type: cosine_accuracy@5 value: 0.8722741433021807 name: Cosine Accuracy@5 - type: cosine_accuracy@10 value: 0.9086188992731049 name: Cosine Accuracy@10 - type: cosine_precision@1 value: 0.6656282450674974 name: Cosine Precision@1 - type: cosine_precision@3 value: 0.2782969885773624 name: Cosine Precision@3 - type: cosine_precision@5 value: 0.17445482866043613 name: Cosine Precision@5 - type: cosine_precision@10 value: 0.0908618899273105 name: Cosine Precision@10 - type: cosine_recall@1 value: 0.6656282450674974 name: Cosine Recall@1 - type: cosine_recall@3 value: 0.8348909657320872 name: Cosine Recall@3 - type: cosine_recall@5 value: 0.8722741433021807 name: Cosine Recall@5 - type: cosine_recall@10 value: 0.9086188992731049 name: Cosine Recall@10 - type: cosine_ndcg@10 value: 0.7933420644079736 name: Cosine Ndcg@10 - type: cosine_mrr@10 value: 0.7556783530303787 name: Cosine Mrr@10 - type: cosine_map@100 value: 0.7586459019483849 name: Cosine Map@100 --- # SentenceTransformer based on intfloat/multilingual-e5-large-instruct This is a [sentence-transformers](https://www.SBERT.net) model finetuned from [intfloat/multilingual-e5-large-instruct](https://huggingface.co/intfloat/multilingual-e5-large-instruct) on the clef-me5-triplets-hard-negatives dataset. It maps sentences & paragraphs to a 1024-dimensional dense vector space and can be used for retrieval. ## Model Details ### Model Description - **Model Type:** Sentence Transformer - **Base model:** [intfloat/multilingual-e5-large-instruct](https://huggingface.co/intfloat/multilingual-e5-large-instruct) - **Maximum Sequence Length:** 256 tokens - **Output Dimensionality:** 1024 dimensions - **Similarity Function:** Cosine Similarity - **Supported...
